Drug interactions
Docetaxel + Tepotinib
Severity: Moderate
Docetaxel and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein in vitro and in clinical studies raised exposure of the P-gp substrate dabigatran. Docetaxel is a P-gp substrate, so its levels and toxicity (neutropenia, neuropathy, fluid retention) could rise. Clinical data with docetaxel are lacking.
What this interaction means in plain words
Docetaxel and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux, which may increase docetaxel absorption and tissue exposure.
What to do
Monitor blood counts and signs of docetaxel toxicity closely, and reduce the docetaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Docetaxel with Tepotinib?
MediHelp rates the interaction as moderate. Docetaxel and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein in vitro and in clinical studies raised exposure of the P-gp substrate dabigatran. Docetaxel is a P-gp substrate, so its levels and toxicity (neutropenia, neuropathy, fluid retention) could rise. Clinical data with docetaxel are lacking.
How serious is the interaction between Docetaxel and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of docetaxel toxicity closely, and reduce the docetaxel dose if toxicity develops.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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