Drug interactions
Docetaxel + Tucatinib
Severity: Major
Docetaxel and Tucatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor, and docetaxel is extensively metabolized by CYP3A4. Higher docetaxel exposure can increase neutropenia, mucositis, neuropathy and fluid retention.
What this interaction means in plain words
Docetaxel and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Docetaxel belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing docetaxel metabolic clearance.
What to do
Avoid the combination if possible; if used, monitor blood counts and toxicity closely and consider reducing the docetaxel dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Docetaxel
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Docetaxel with Tucatinib?
MediHelp rates the interaction as major. Docetaxel and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a moderate CYP3A inhibitor, and docetaxel is extensively metabolized by CYP3A4. Higher docetaxel exposure can increase neutropenia, mucositis, neuropathy and fluid retention.
How serious is the interaction between Docetaxel and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor blood counts and toxicity closely and consider reducing the docetaxel dose.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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