Drug interactions
Dofetilide + Indapamide
Severity: Major
Dofetilide and Indapamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a high risk of torsades de pointes, which is increased by hypokalemia and hypomagnesemia. Indapamide can cause these electrolyte disturbances, and thiazide-type diuretics may also reduce dofetilide clearance.
What this interaction means in plain words
Dofetilide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte loss.
What to do
Avoid unless electrolytes are closely controlled, and monitor ECG, renal function, potassium and magnesium. Consider a potassium-sparing alternative or a different antihypertensive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indapamide
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Indapamide?
MediHelp rates the interaction as major. Dofetilide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide has a high risk of torsades de pointes, which is increased by hypokalemia and hypomagnesemia. Indapamide can cause these electrolyte disturbances, and thiazide-type diuretics may also reduce dofetilide clearance.
How serious is the interaction between Dofetilide and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless electrolytes are closely controlled, and monitor ECG, renal function, potassium and magnesium. Consider a potassium-sparing alternative or a different antihypertensive.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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