Drug interactions
Dofetilide + Metformin-sitagliptin
Severity: Moderate
Dofetilide and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is secreted by renal cationic transporters and may compete with metformin for tubular secretion, raising metformin levels. Metformin accumulation can increase the risk of lactic acidosis, particularly with renal impairment.
What this interaction means in plain words
Dofetilide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) reduces metformin clearance.
What to do
Monitor renal function and blood glucose, and consider reducing metformin dose if renal function is impaired; watch for signs of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Dofetilide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide is secreted by renal cationic transporters and may compete with metformin for tubular secretion, raising metformin levels. Metformin accumulation can increase the risk of lactic acidosis, particularly with renal impairment.
How serious is the interaction between Dofetilide and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood glucose, and consider reducing metformin dose if renal function is impaired; watch for signs of lactic acidosis.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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