Drug interactions
Dofetilide + Metformin
Severity: Moderate
Dofetilide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide and metformin are both secreted by renal cationic transport, so dofetilide may raise metformin levels. The effect is probably small, but metformin accumulation matters in renal impairment. Dofetilide itself is also sensitive to renal function.
What this interaction means in plain words
Dofetilide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic secretion (OCT2/MATE) reduces metformin clearance.
What to do
Monitor renal function and for metformin adverse effects such as GI intolerance or lactic acidosis. Reduce the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Metformin?
MediHelp rates the interaction as moderate. Dofetilide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide and metformin are both secreted by renal cationic transport, so dofetilide may raise metformin levels. The effect is probably small, but metformin accumulation matters in renal impairment. Dofetilide itself is also sensitive to renal function.
How serious is the interaction between Dofetilide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin adverse effects such as GI intolerance or lactic acidosis. Reduce the metformin dose if renal function declines.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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