Drug interactions
Dofetilide + Tenofovir disoproxil
Severity: Major
Dofetilide and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal tubular secretion, and tenofovir could compete with dofetilide for elimination and raise its levels. Higher dofetilide exposure risks QT prolongation and torsades de pointes.
What this interaction means in plain words
Dofetilide and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible competition for renal tubular secretion via organic cation transporters, reducing dofetilide clearance.
What to do
Monitor QTc and renal function closely, with dofetilide dosing based on creatinine clearance. Consider an alternative antiarrhythmic if QT prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Tenofovir disoproxil?
MediHelp rates the interaction as major. Dofetilide and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs undergo renal tubular secretion, and tenofovir could compete with dofetilide for elimination and raise its levels. Higher dofetilide exposure risks QT prolongation and torsades de pointes.
How serious is the interaction between Dofetilide and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor QTc and renal function closely, with dofetilide dosing based on creatinine clearance. Consider an alternative antiarrhythmic if QT prolongation develops.
What other medicines interact with Dofetilide?
MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.
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