Drug interactions
Dolasetron + Fluoxetine
Severity: Moderate
Dolasetron and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported rarely when 5-HT3 antagonists are used with SSRIs such as fluoxetine. Fluoxetine also inhibits CYP2D6, which is involved in metabolism of hydrodolasetron, and it can modestly prolong QT.
What this interaction means in plain words
Dolasetron and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Fluoxetine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects plus CYP2D6 inhibition that may raise hydrodolasetron exposure and QT effect.
What to do
Monitor for signs of serotonin toxicity and consider an ECG if other QT risk factors are present. Use a different antiemetic if the patient is at high arrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dolasetron with Fluoxetine?
MediHelp rates the interaction as moderate. Dolasetron and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported rarely when 5-HT3 antagonists are used with SSRIs such as fluoxetine. Fluoxetine also inhibits CYP2D6, which is involved in metabolism of hydrodolasetron, and it can modestly prolong QT.
How serious is the interaction between Dolasetron and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and consider an ECG if other QT risk factors are present. Use a different antiemetic if the patient is at high arrhythmia risk.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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