Drug interactions
Dolasetron + Fluticasone-vilanterol
Severity: Major
Dolasetron and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron prolongs the QT interval through its active metabolite hydrodolasetron, and vilanterol can add to this effect, particularly with hypokalemia. Torsades de pointes is a potential risk.
What this interaction means in plain words
Dolasetron and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QTc prolongation, with beta-agonist-induced hypokalemia and adrenergic stimulation adding to the risk.
What to do
Prefer a non-QT-prolonging antiemetic such as another 5-HT3 antagonist with less effect, or monitor ECG and correct potassium and magnesium if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Dolasetron and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dolasetron prolongs the QT interval through its active metabolite hydrodolasetron, and vilanterol can add to this effect, particularly with hypokalemia. Torsades de pointes is a potential risk.
How serious is the interaction between Dolasetron and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antiemetic such as another 5-HT3 antagonist with less effect, or monitor ECG and correct potassium and magnesium if combined.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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