Drug interactions
Dolasetron + Ipratropium-salbutamol
Severity: Moderate
Dolasetron and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron can prolong PR, QRS and QT intervals, and salbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The concern is greatest with high salbutamol doses or existing electrolyte disturbance.
What this interaction means in plain words
Dolasetron and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia increasing risk.
What to do
Correct potassium and magnesium before use and obtain an ECG in patients with cardiac risk factors. Consider an alternative antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Dolasetron and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron can prolong PR, QRS and QT intervals, and salbutamol may add to arrhythmic risk through tachycardia and hypokalemia. The concern is greatest with high salbutamol doses or existing electrolyte disturbance.
How serious is the interaction between Dolasetron and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before use and obtain an ECG in patients with cardiac risk factors. Consider an alternative antiemetic in high-risk patients.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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