Drug interactions
Dolasetron + Lapatinib
Severity: Moderate
Dolasetron and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib prolongs the QT interval in a concentration-related way and dolasetron has similar effects. The combination may increase the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Dolasetron and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Lapatinib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Perform ECG monitoring and correct electrolyte abnormalities. Prefer an antiemetic without QT effect if QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dolasetron with Lapatinib?
MediHelp rates the interaction as moderate. Dolasetron and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib prolongs the QT interval in a concentration-related way and dolasetron has similar effects. The combination may increase the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Dolasetron and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring and correct electrolyte abnormalities. Prefer an antiemetic without QT effect if QTc is already prolonged.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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