Drug interactions
Dolasetron + Levofloxacin
Severity: Major
Dolasetron and Levofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin and dolasetron can each prolong the QT interval, so co-administration may increase the risk of serious ventricular arrhythmias. The danger is greater with hypokalemia, bradycardia or structural heart disease.
What this interaction means in plain words
Dolasetron and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive blockade of cardiac potassium channels delaying repolarization.
What to do
Avoid if possible by choosing an antiemetic or antibiotic with less QT effect. If needed, obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Dolasetron with Levofloxacin?
MediHelp rates the interaction as major. Dolasetron and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levofloxacin and dolasetron can each prolong the QT interval, so co-administration may increase the risk of serious ventricular arrhythmias. The danger is greater with hypokalemia, bradycardia or structural heart disease.
How serious is the interaction between Dolasetron and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible by choosing an antiemetic or antibiotic with less QT effect. If needed, obtain an ECG and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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