Drug interactions
Dolasetron + Maprotiline
Severity: Major
Dolasetron and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, can prolong QT and QRS intervals, particularly in overdose or in patients with cardiac disease. Added to dolasetron, the risk of ventricular arrhythmia increases.
What this interaction means in plain words
Dolasetron and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Maprotiline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction through ion channel blockade.
What to do
Use an alternative antiemetic if possible. If both are required, obtain a baseline ECG, correct electrolytes, and monitor QTc and QRS duration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dolasetron with Maprotiline?
MediHelp rates the interaction as major. Dolasetron and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline, a tetracyclic antidepressant, can prolong QT and QRS intervals, particularly in overdose or in patients with cardiac disease. Added to dolasetron, the risk of ventricular arrhythmia increases.
How serious is the interaction between Dolasetron and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiemetic if possible. If both are required, obtain a baseline ECG, correct electrolytes, and monitor QTc and QRS duration.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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