Drug interactions
Dolasetron + Propafenone
Severity: Major
Dolasetron and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong cardiac conduction and the QT interval. Giving them together adds to the risk of torsades de pointes and other serious ventricular arrhythmias, especially with electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Dolasetron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization and conduction (the active metabolite of dolasetron, hydrodolasetron, blocks sodium and potassium channels).
What to do
Prefer an antiemetic with less cardiac effect, such as a different class, if propafenone is needed. If unavoidable, correct potassium and magnesium first and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Dolasetron with Propafenone?
MediHelp rates the interaction as major. Dolasetron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong cardiac conduction and the QT interval. Giving them together adds to the risk of torsades de pointes and other serious ventricular arrhythmias, especially with electrolyte disturbances or structural heart disease.
How serious is the interaction between Dolasetron and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less cardiac effect, such as a different class, if propafenone is needed. If unavoidable, correct potassium and magnesium first and monitor the ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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