Drug interactions
Dolasetron + Sertraline
Severity: Moderate
Dolasetron and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported when 5-HT3 antagonists are given with serotonergic antidepressants such as SSRIs. Sertraline also has a small QT effect, which adds to dolasetron's own QT liability.
What this interaction means in plain words
Dolasetron and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect, plus minor additive QT prolongation.
What to do
Monitor for signs of serotonin toxicity and consider an ECG in patients with cardiac risk factors. Choose an alternative antiemetic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Dolasetron with Sertraline?
MediHelp rates the interaction as moderate. Dolasetron and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported when 5-HT3 antagonists are given with serotonergic antidepressants such as SSRIs. Sertraline also has a small QT effect, which adds to dolasetron's own QT liability.
How serious is the interaction between Dolasetron and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and consider an ECG in patients with cardiac risk factors. Choose an alternative antiemetic if risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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