Drug interactions
Dolasetron + Sumatriptan
Severity: Moderate
Dolasetron and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported with triptans and 5-HT3 antagonists, although it is uncommon. Symptoms include agitation, tremor, diarrhea, sweating, and fever.
What this interaction means in plain words
Dolasetron and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; the mechanism is largely theoretical.
What to do
Counsel the patient on symptoms of serotonin toxicity and monitor after starting the combination. Stop both drugs if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Dolasetron with Sumatriptan?
MediHelp rates the interaction as moderate. Dolasetron and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported with triptans and 5-HT3 antagonists, although it is uncommon. Symptoms include agitation, tremor, diarrhea, sweating, and fever.
How serious is the interaction between Dolasetron and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin toxicity and monitor after starting the combination. Stop both drugs if symptoms develop.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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