Drug interactions
Dolasetron + Umeclidinium-vilanterol
Severity: Moderate
Dolasetron and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs the PR, QRS and QT intervals. Vilanterol may add tachycardia and potassium lowering, which could further increase arrhythmia risk.
What this interaction means in plain words
Dolasetron and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-adrenergic cardiac stimulation.
What to do
Consider an alternative antiemetic such as a lower-risk 5-HT3 antagonist in patients with cardiac risk factors. Monitor ECG and electrolytes if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Dolasetron and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron's active metabolite prolongs the PR, QRS and QT intervals. Vilanterol may add tachycardia and potassium lowering, which could further increase arrhythmia risk.
How serious is the interaction between Dolasetron and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiemetic such as a lower-risk 5-HT3 antagonist in patients with cardiac risk factors. Monitor ECG and electrolytes if combined.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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