Drug interactions
Dolutegravir + Linagliptin-metformin
Severity: Moderate
Dolutegravir and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir raises metformin plasma concentrations, which can increase metformin adverse effects including lactic acidosis risk. The effect is clinically relevant at higher metformin doses.
What this interaction means in plain words
Dolutegravir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Linagliptin-metformin belongs to Endocrine.
Why it happens
Dolutegravir inhibits OCT2 and MATE1 transporters, reducing renal and hepatic clearance of metformin.
What to do
Limit total daily metformin to about 1000 mg when used with dolutegravir, and monitor glucose and renal function. Readjust metformin when dolutegravir is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Dolutegravir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir raises metformin plasma concentrations, which can increase metformin adverse effects including lactic acidosis risk. The effect is clinically relevant at higher metformin doses.
How serious is the interaction between Dolutegravir and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit total daily metformin to about 1000 mg when used with dolutegravir, and monitor glucose and renal function. Readjust metformin when dolutegravir is started or stopped.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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