Drug interactions
Dolutegravir + Saxagliptin-metformin
Severity: Moderate
Dolutegravir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir raises metformin concentrations by inhibiting its renal and hepatic transport. This can increase metformin adverse effects, including gastrointestinal intolerance and a risk of lactic acidosis.
What this interaction means in plain words
Dolutegravir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2 and MATE1 transporters, decreasing renal tubular secretion of metformin.
What to do
Limit the total daily metformin dose to 1,000 mg when starting either drug, and monitor blood glucose and renal function. Readjust metformin after stopping dolutegravir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Dolutegravir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir raises metformin concentrations by inhibiting its renal and hepatic transport. This can increase metformin adverse effects, including gastrointestinal intolerance and a risk of lactic acidosis.
How serious is the interaction between Dolutegravir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to 1,000 mg when starting either drug, and monitor blood glucose and renal function. Readjust metformin after stopping dolutegravir.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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