Drug interactions
Dopamine + Procarbazine
Severity: Major
Dopamine and Procarbazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity, which blocks dopamine breakdown and markedly potentiates its pressor effect. This can cause a hypertensive crisis.
What this interaction means in plain words
Dopamine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dopamine belongs to Cardiovascular; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition reduces metabolism of dopamine, increasing its availability and sympathomimetic effects.
What to do
Avoid if possible; if dopamine is essential, start at a much reduced dose with continuous blood pressure monitoring and have an antihypertensive available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Dopamine with Procarbazine?
MediHelp rates the interaction as major. Dopamine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has monoamine oxidase inhibiting activity, which blocks dopamine breakdown and markedly potentiates its pressor effect. This can cause a hypertensive crisis.
How serious is the interaction between Dopamine and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if dopamine is essential, start at a much reduced dose with continuous blood pressure monitoring and have an antihypertensive available.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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