Drug interactions
Dopamine + Tolcapone
Severity: Moderate
Dopamine and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone inhibits COMT, one of the enzymes that degrades catecholamines, so the effects of exogenous dopamine may be prolonged or enhanced. This can lead to excessive increases in heart rate and blood pressure or arrhythmias.
What this interaction means in plain words
Dopamine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Tolcapone belongs to Central Nervous System.
Why it happens
Inhibition of catechol-O-methyltransferase by tolcapone reduces the metabolism of dopamine.
What to do
Monitor heart rate, rhythm and blood pressure when dopamine is given to a patient taking tolcapone, and start dopamine at a low rate with careful titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Dopamine with Tolcapone?
MediHelp rates the interaction as moderate. Dopamine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolcapone inhibits COMT, one of the enzymes that degrades catecholamines, so the effects of exogenous dopamine may be prolonged or enhanced. This can lead to excessive increases in heart rate and blood pressure or arrhythmias.
How serious is the interaction between Dopamine and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure when dopamine is given to a patient taking tolcapone, and start dopamine at a low rate with careful titration.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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