Drug interactions
Doravirine + Ketoconazole
Severity: Minor
Doravirine and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises doravirine concentrations moderately. Doravirine is generally well tolerated, so the increase is usually of limited clinical significance.
What this interaction means in plain words
Doravirine and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doravirine belongs to Anti Virals; Ketoconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces doravirine metabolism.
What to do
No dose adjustment of doravirine is generally required. Monitor for adverse effects such as nausea or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Doravirine with Ketoconazole?
MediHelp rates the interaction as minor. Doravirine and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole raises doravirine concentrations moderately. Doravirine is generally well tolerated, so the increase is usually of limited clinical significance.
How serious is the interaction between Doravirine and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of doravirine is generally required. Monitor for adverse effects such as nausea or headache.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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