Drug interactions
Doravirine + Lorlatinib
Severity: Major
Doravirine and Lorlatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce doravirine exposure through CYP3A4 induction. Lower antiretroviral levels could risk virologic failure and resistance.
What this interaction means in plain words
Doravirine and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doravirine belongs to Anti Virals; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, which is the main metabolic pathway of doravirine.
What to do
Monitor HIV viral load closely, or consider an alternative antiretroviral regimen. Doravirine labeling advises a dose increase with rifabutin, a weaker inducer, but no specific recommendation exists for lorlatinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Doravirine with Lorlatinib?
MediHelp rates the interaction as major. Doravirine and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib may reduce doravirine exposure through CYP3A4 induction. Lower antiretroviral levels could risk virologic failure and resistance.
How serious is the interaction between Doravirine and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load closely, or consider an alternative antiretroviral regimen. Doravirine labeling advises a dose increase with rifabutin, a weaker inducer, but no specific recommendation exists for lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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