Drug interactions
Doravirine + Rifabutin
Severity: Moderate
Doravirine and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin lowers doravirine concentrations, which could lead to loss of virologic suppression and resistance. The effect is moderate and can be offset by dose adjustment.
What this interaction means in plain words
Doravirine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doravirine belongs to Anti Virals; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, increasing doravirine metabolism.
What to do
Increase doravirine to 100 mg twice daily during rifabutin co-administration. Return to once daily dosing about 2 weeks after rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Doravirine with Rifabutin?
MediHelp rates the interaction as moderate. Doravirine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin lowers doravirine concentrations, which could lead to loss of virologic suppression and resistance. The effect is moderate and can be offset by dose adjustment.
How serious is the interaction between Doravirine and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase doravirine to 100 mg twice daily during rifabutin co-administration. Return to once daily dosing about 2 weeks after rifabutin is stopped.
What other medicines interact with Doravirine?
MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.
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