Drug interactions
Dorzolamide + Lisdexamfetamine
Severity: Minor
Dorzolamide and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic carbonic anhydrase inhibitors alkalinize urine and reduce renal elimination of amphetamine, but dorzolamide is used topically in the eye with minimal systemic effect on urine pH. A clinically meaningful interaction is unlikely.
What this interaction means in plain words
Dorzolamide and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dorzolamide belongs to Miscellaneous; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Theoretical urinary alkalinization decreasing amphetamine renal clearance; minimal with topical dorzolamide.
What to do
No action is usually required with ophthalmic dorzolamide. Monitor for amphetamine excess if urinary alkalinizing agents are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dorzolamide with Lisdexamfetamine?
MediHelp rates the interaction as minor. Dorzolamide and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic carbonic anhydrase inhibitors alkalinize urine and reduce renal elimination of amphetamine, but dorzolamide is used topically in the eye with minimal systemic effect on urine pH. A clinically meaningful interaction is unlikely.
How serious is the interaction between Dorzolamide and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually required with ophthalmic dorzolamide. Monitor for amphetamine excess if urinary alkalinizing agents are also used.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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