Drug interactions
Dosulepin + Propofol
Severity: Moderate
Dosulepin and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin, a sedating tricyclic antidepressant, increases CNS depression with propofol. Hypotension and arrhythmia risk may also be heightened.
What this interaction means in plain words
Dosulepin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus tricyclic effects on cardiac conduction and blood pressure.
What to do
Titrate propofol cautiously and monitor sedation, blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Propofol?
MediHelp rates the interaction as moderate. Dosulepin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin, a sedating tricyclic antidepressant, increases CNS depression with propofol. Hypotension and arrhythmia risk may also be heightened.
How serious is the interaction between Dosulepin and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor sedation, blood pressure and ECG.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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