Drug interactions
Doxepin + Eletriptan
Severity: Moderate
Doxepin and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, inhibits serotonin reuptake and combined with a triptan may theoretically contribute to serotonin syndrome. Reported cases with triptans are rare.
What this interaction means in plain words
Doxepin and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and triptan 5-HT1 agonism.
What to do
Monitor for signs of serotonin toxicity when starting or raising doses. Counsel patients to report agitation, tremor, sweating or fever.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Eletriptan?
MediHelp rates the interaction as moderate. Doxepin and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, inhibits serotonin reuptake and combined with a triptan may theoretically contribute to serotonin syndrome. Reported cases with triptans are rare.
How serious is the interaction between Doxepin and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity when starting or raising doses. Counsel patients to report agitation, tremor, sweating or fever.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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