Drug interactions
Doxepin + Estradiol
Severity: Minor
Doxepin and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens have been reported to increase tricyclic antidepressant levels and adverse effects, while possibly reducing antidepressant benefit. Evidence is limited and mostly historical.
What this interaction means in plain words
Doxepin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Estradiol belongs to Endocrine.
Why it happens
Mechanism is not well established; altered hepatic metabolism of the tricyclic has been suggested.
What to do
Monitor for sedation, anticholinergic effects and hypotension, and titrate doxepin to clinical response when estrogen therapy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Estradiol?
MediHelp rates the interaction as minor. Doxepin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens have been reported to increase tricyclic antidepressant levels and adverse effects, while possibly reducing antidepressant benefit. Evidence is limited and mostly historical.
How serious is the interaction between Doxepin and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and hypotension, and titrate doxepin to clinical response when estrogen therapy changes.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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