Drug interactions
Doxepin + Glipizide
Severity: Minor
Doxepin and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin may alter glucose homeostasis and have been reported to enhance hypoglycemia with antidiabetic agents in some patients, while also causing weight gain that worsens control. Effects are inconsistent and usually modest.
What this interaction means in plain words
Doxepin and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Glipizide belongs to Endocrine.
Why it happens
Possible effects on insulin sensitivity and glucose metabolism; the mechanism is not firmly established.
What to do
Monitor blood glucose when doxepin is started, stopped or changed in dose, and adjust glipizide if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Glipizide?
MediHelp rates the interaction as minor. Doxepin and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin may alter glucose homeostasis and have been reported to enhance hypoglycemia with antidiabetic agents in some patients, while also causing weight gain that worsens control. Effects are inconsistent and usually modest.
How serious is the interaction between Doxepin and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started, stopped or changed in dose, and adjust glipizide if needed.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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