Drug interactions
Doxepin + Goserelin
Severity: Moderate
Doxepin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin can prolong QT, particularly at higher doses or in overdose, and goserelin may add to this. Risk is highest in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Doxepin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use the lowest effective doxepin dose and obtain an ECG in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Goserelin?
MediHelp rates the interaction as moderate. Doxepin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as doxepin can prolong QT, particularly at higher doses or in overdose, and goserelin may add to this. Risk is highest in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Doxepin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doxepin dose and obtain an ECG in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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