Drug interactions
Doxepin + Indacaterol
Severity: Moderate
Doxepin and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant that can prolong the QT interval and cause tachycardia at antidepressant doses. Indacaterol may add to cardiovascular stimulation and QT effects. Arrhythmia risk may be higher in susceptible patients.
What this interaction means in plain words
Doxepin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects.
What to do
Monitor ECG and heart rate in patients with cardiac disease, and check electrolytes if risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Indacaterol?
MediHelp rates the interaction as moderate. Doxepin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant that can prolong the QT interval and cause tachycardia at antidepressant doses. Indacaterol may add to cardiovascular stimulation and QT effects. Arrhythmia risk may be higher in susceptible patients.
How serious is the interaction between Doxepin and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate in patients with cardiac disease, and check electrolytes if risk factors exist.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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