Drug interactions
Doxepin + Methamphetamine
Severity: Major
Doxepin and Methamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic, can alter the response to methamphetamine. Cardiovascular stimulation, arrhythmia and serotonin toxicity are possible, and methamphetamine exposure may increase.
What this interaction means in plain words
Doxepin and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxepin belongs to Dermatology; Methamphetamine belongs to Central Nervous System.
Why it happens
Norepinephrine reuptake blockade and CYP2D6 inhibition produce additive adrenergic effects and possibly higher methamphetamine levels.
What to do
Avoid if possible. If both are needed, use low doses and monitor blood pressure, heart rate, ECG and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Methamphetamine?
MediHelp rates the interaction as major. Doxepin and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxepin, a tricyclic, can alter the response to methamphetamine. Cardiovascular stimulation, arrhythmia and serotonin toxicity are possible, and methamphetamine exposure may increase.
How serious is the interaction between Doxepin and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are needed, use low doses and monitor blood pressure, heart rate, ECG and signs of serotonin toxicity.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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