Drug interactions
Doxepin + Midodrine
Severity: Moderate
Doxepin and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin inhibits norepinephrine reuptake and can modify responses to vasopressors. With midodrine this may cause exaggerated pressor effects or unpredictable blood pressure changes.
What this interaction means in plain words
Doxepin and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Midodrine belongs to Miscellaneous.
Why it happens
Inhibition of norepinephrine reuptake by doxepin alters adrenergic responses to midodrine.
What to do
Monitor blood pressure and heart rate, including supine values. Lower midodrine dose if supine hypertension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Midodrine?
MediHelp rates the interaction as moderate. Doxepin and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin inhibits norepinephrine reuptake and can modify responses to vasopressors. With midodrine this may cause exaggerated pressor effects or unpredictable blood pressure changes.
How serious is the interaction between Doxepin and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including supine values. Lower midodrine dose if supine hypertension appears.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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