Drug interactions
Doxepin + Oxycodone
Severity: Moderate
Doxepin and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and combining it with oxycodone increases drowsiness, psychomotor impairment and potentially respiratory depression. Both drugs also have anticholinergic or constipating effects, and serotonergic activity is a theoretical additional concern.
What this interaction means in plain words
Doxepin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antihistaminic/sedating tricyclic effects.
What to do
Start with low doses and monitor for sedation, confusion and constipation, especially in older adults. Reduce the dose of either drug if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Oxycodone?
MediHelp rates the interaction as moderate. Doxepin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and combining it with oxycodone increases drowsiness, psychomotor impairment and potentially respiratory depression. Both drugs also have anticholinergic or constipating effects, and serotonergic activity is a theoretical additional concern.
How serious is the interaction between Doxepin and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation, confusion and constipation, especially in older adults. Reduce the dose of either drug if excess sedation occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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