Drug interactions
Doxepin + Pregabalin
Severity: Moderate
Doxepin and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and with pregabalin it can cause additive drowsiness, dizziness and psychomotor impairment, especially in older patients.
What this interaction means in plain words
Doxepin and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Start low and titrate slowly while monitoring for sedation, confusion and falls. Counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Pregabalin?
MediHelp rates the interaction as moderate. Doxepin and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and with pregabalin it can cause additive drowsiness, dizziness and psychomotor impairment, especially in older patients.
How serious is the interaction between Doxepin and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low and titrate slowly while monitoring for sedation, confusion and falls. Counsel on driving.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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