Drug interactions
Doxepin + Rizatriptan
Severity: Moderate
Doxepin and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic transmission, so combined use may rarely lead to serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. The risk is generally low but rises with dose increases or additional serotonergic agents.
What this interaction means in plain words
Doxepin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism with doxepin-mediated inhibition of serotonin reuptake.
What to do
Monitor for signs of serotonin syndrome, especially when starting or increasing either drug. Stop the serotonergic agents and treat supportively if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Rizatriptan?
MediHelp rates the interaction as moderate. Doxepin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic transmission, so combined use may rarely lead to serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. The risk is generally low but rises with dose increases or additional serotonergic agents.
How serious is the interaction between Doxepin and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially when starting or increasing either drug. Stop the serotonergic agents and treat supportively if symptoms appear.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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