Drug interactions
Doxepin + Sevoflurane
Severity: Moderate
Doxepin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant that adds to sevoflurane's CNS depression and can cause hypotension and anticholinergic effects. Both agents may prolong the QT interval and tricyclics can increase arrhythmia risk.
What this interaction means in plain words
Doxepin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive effects on cardiac repolarization, with antihistamine and alpha-blocking contributions.
What to do
Monitor ECG, blood pressure and depth of anesthesia, and correct electrolyte disturbances beforehand. Avoid adding other QT-prolonging drugs and observe recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Sevoflurane?
MediHelp rates the interaction as moderate. Doxepin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant that adds to sevoflurane's CNS depression and can cause hypotension and anticholinergic effects. Both agents may prolong the QT interval and tricyclics can increase arrhythmia risk.
How serious is the interaction between Doxepin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, blood pressure and depth of anesthesia, and correct electrolyte disturbances beforehand. Avoid adding other QT-prolonging drugs and observe recovery.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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