Drug interactions
Doxepin + Sotalol
Severity: Major
Doxepin and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol prolongs the QT interval, and doxepin, a tricyclic antidepressant, may add modest QT and conduction effects. The risk of ventricular arrhythmia is increased, mainly at higher doses or with electrolyte disturbance.
What this interaction means in plain words
Doxepin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxepin belongs to Dermatology; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation and effects on cardiac conduction.
What to do
Avoid if feasible; if combined, use the lowest doxepin dose, correct potassium and magnesium, and monitor QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Sotalol?
MediHelp rates the interaction as major. Doxepin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol prolongs the QT interval, and doxepin, a tricyclic antidepressant, may add modest QT and conduction effects. The risk of ventricular arrhythmia is increased, mainly at higher doses or with electrolyte disturbance.
How serious is the interaction between Doxepin and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible; if combined, use the lowest doxepin dose, correct potassium and magnesium, and monitor QTc.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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