Drug interactions
Doxepin + Tedizolid
Severity: Moderate
Doxepin and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and doxepin is a tricyclic that inhibits serotonin and norepinephrine reuptake. Serotonin syndrome is theoretically possible, though clinical evidence with tedizolid is limited.
What this interaction means in plain words
Doxepin and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Tedizolid belongs to Anti Bacterial.
Why it happens
Potential additive serotonergic effect from weak MAO inhibition and reuptake inhibition.
What to do
Monitor for signs of serotonin toxicity, especially with higher doxepin doses. Consider an alternative antibiotic if the patient has a high serotonergic burden.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Tedizolid?
MediHelp rates the interaction as moderate. Doxepin and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor, and doxepin is a tricyclic that inhibits serotonin and norepinephrine reuptake. Serotonin syndrome is theoretically possible, though clinical evidence with tedizolid is limited.
How serious is the interaction between Doxepin and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity, especially with higher doxepin doses. Consider an alternative antibiotic if the patient has a high serotonergic burden.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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