Drug interactions
Doxepin + Tiotropium-olodaterol
Severity: Moderate
Doxepin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic properties that add to tiotropium, and tricyclic antidepressants can prolong QT and potentiate cardiovascular effects of beta2-agonists. This can increase tachycardia, arrhythmia risk, dry mouth and urinary retention.
What this interaction means in plain words
Doxepin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive cardiac effects, including QT prolongation and adrenergic potentiation.
What to do
Monitor heart rate, ECG in at-risk patients, and anticholinergic effects. Consider using the lowest effective doxepin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Doxepin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin has anticholinergic properties that add to tiotropium, and tricyclic antidepressants can prolong QT and potentiate cardiovascular effects of beta2-agonists. This can increase tachycardia, arrhythmia risk, dry mouth and urinary retention.
How serious is the interaction between Doxepin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG in at-risk patients, and anticholinergic effects. Consider using the lowest effective doxepin dose.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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