Drug interactions
Doxorubicin + Rolapitant
Severity: Minor
Doxorubicin and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is partly metabolized by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure to doxorubicin could increase, raising the potential for myelosuppression and cardiotoxicity, although CYP2D6 is a minor route of its clearance.
What this interaction means in plain words
Doxorubicin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, which may slightly reduce doxorubicin metabolism.
What to do
No empirical dose change is generally needed. Monitor blood counts and cardiac status as usual during doxorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Rolapitant?
MediHelp rates the interaction as minor. Doxorubicin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is partly metabolized by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure to doxorubicin could increase, raising the potential for myelosuppression and cardiotoxicity, although CYP2D6 is a minor route of its clearance.
How serious is the interaction between Doxorubicin and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally needed. Monitor blood counts and cardiac status as usual during doxorubicin therapy.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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