Drug interactions
Doxycycline + Omaveloxolone
Severity: Minor
Doxycycline and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a CYP3A4 substrate, so inhibitors can increase exposure and cause transaminase elevation and other adverse effects. Doxycycline is not recognized as a meaningful CYP3A4 inhibitor, so the risk is mostly theoretical.
What this interaction means in plain words
Doxycycline and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Omaveloxolone belongs to Central Nervous System.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline.
What to do
No empiric dose change; monitor liver enzymes and tolerability as per omaveloxolone labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Doxycycline with Omaveloxolone?
MediHelp rates the interaction as minor. Doxycycline and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone is a CYP3A4 substrate, so inhibitors can increase exposure and cause transaminase elevation and other adverse effects. Doxycycline is not recognized as a meaningful CYP3A4 inhibitor, so the risk is mostly theoretical.
How serious is the interaction between Doxycycline and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; monitor liver enzymes and tolerability as per omaveloxolone labeling.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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