Drug interactions
Doxycycline + Repotrectinib
Severity: Minor
Doxycycline and Repotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is metabolized by CYP3A4, so inhibitors can raise exposure and CNS effects such as dizziness and ataxia. Doxycycline is not an established CYP3A4 inhibitor, so a clinically significant effect is unlikely.
What this interaction means in plain words
Doxycycline and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Repotrectinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline.
What to do
No dose change needed; monitor for dizziness, ataxia and other neurologic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Doxycycline with Repotrectinib?
MediHelp rates the interaction as minor. Doxycycline and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repotrectinib is metabolized by CYP3A4, so inhibitors can raise exposure and CNS effects such as dizziness and ataxia. Doxycycline is not an established CYP3A4 inhibitor, so a clinically significant effect is unlikely.
How serious is the interaction between Doxycycline and Repotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor for dizziness, ataxia and other neurologic adverse effects.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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