Drug interactions
Dronabinol + Letermovir
Severity: Moderate
Dronabinol and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately, which may raise dronabinol concentrations. Patients may experience stronger sedation, dizziness, tachycardia or mood and cognitive effects.
What this interaction means in plain words
Dronabinol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, decreasing the first-pass and hepatic metabolism of dronabinol.
What to do
Monitor for increased cannabinoid effects and reduce the dronabinol dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Dronabinol with Letermovir?
MediHelp rates the interaction as moderate. Dronabinol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 moderately, which may raise dronabinol concentrations. Patients may experience stronger sedation, dizziness, tachycardia or mood and cognitive effects.
How serious is the interaction between Dronabinol and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased cannabinoid effects and reduce the dronabinol dose if they occur.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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