Drug interactions
Dronabinol + Lurasidone
Severity: Moderate
Dronabinol and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol causes sedation, dizziness and cognitive effects and may worsen psychosis. With lurasidone, CNS depression may be additive and psychiatric symptoms may be harder to control.
What this interaction means in plain words
Dronabinol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with cannabinoid-related psychotomimetic effects.
What to do
Monitor sedation and mental state. Use the lowest effective dronabinol dose and reassess if psychotic symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronabinol and Lurasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Lurasidone?
MediHelp rates the interaction as moderate. Dronabinol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronabinol causes sedation, dizziness and cognitive effects and may worsen psychosis. With lurasidone, CNS depression may be additive and psychiatric symptoms may be harder to control.
How serious is the interaction between Dronabinol and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental state. Use the lowest effective dronabinol dose and reassess if psychotic symptoms worsen.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
