Drug interactions
Dronedarone + Edoxaban
Severity: Moderate
Dronedarone and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and raises edoxaban exposure, which could increase bleeding risk. The effect is clinically relevant, especially in patients with renal impairment or low body weight.
What this interaction means in plain words
Dronedarone and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Dronedarone inhibits P-gp-mediated efflux of edoxaban, increasing its absorption.
What to do
For VTE treatment, reduce edoxaban to 30 mg daily; no reduction is recommended for atrial fibrillation. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Dronedarone with Edoxaban?
MediHelp rates the interaction as moderate. Dronedarone and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits P-glycoprotein and raises edoxaban exposure, which could increase bleeding risk. The effect is clinically relevant, especially in patients with renal impairment or low body weight.
How serious is the interaction between Dronedarone and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For VTE treatment, reduce edoxaban to 30 mg daily; no reduction is recommended for atrial fibrillation. Monitor for bleeding.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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