Drug interactions
Dronedarone + Indacaterol-glycopyrronium
Severity: Major
Dronedarone and Indacaterol-glycopyrronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and can cause torsades de pointes. Indacaterol may add to cardiac repolarization effects and lower potassium, increasing arrhythmia risk. Dronedarone also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure.
What this interaction means in plain words
Dronedarone and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation; dronedarone inhibition of CYP3A4 and P-glycoprotein may increase indacaterol exposure.
What to do
Check ECG, potassium and magnesium at baseline and during therapy. Watch for palpitations or syncope and review other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Dronedarone and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone prolongs the QT interval and can cause torsades de pointes. Indacaterol may add to cardiac repolarization effects and lower potassium, increasing arrhythmia risk. Dronedarone also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure.
How serious is the interaction between Dronedarone and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium at baseline and during therapy. Watch for palpitations or syncope and review other QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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