Drug interactions
Dronedarone + Ivacaftor
Severity: Moderate
Dronedarone and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, can increase ivacaftor exposure. Greater exposure may increase ivacaftor adverse effects such as transaminase elevation and headache.
What this interaction means in plain words
Dronedarone and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ivacaftor.
What to do
Reduce ivacaftor dosing frequency as specified in the labeling for moderate CYP3A inhibitors for the particular ivacaftor-containing product. Monitor liver enzymes and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Dronedarone with Ivacaftor?
MediHelp rates the interaction as moderate. Dronedarone and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone, a moderate CYP3A4 inhibitor, can increase ivacaftor exposure. Greater exposure may increase ivacaftor adverse effects such as transaminase elevation and headache.
How serious is the interaction between Dronedarone and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ivacaftor dosing frequency as specified in the labeling for moderate CYP3A inhibitors for the particular ivacaftor-containing product. Monitor liver enzymes and tolerability.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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