Drug interactions
Dronedarone + Lomitapide
Severity: Major
Dronedarone and Lomitapide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, can raise lomitapide levels, increasing risk of hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Dronedarone and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 metabolism of lomitapide.
What to do
Avoid combination; if needed, limit lomitapide dose per labeling and monitor liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Dronedarone with Lomitapide?
MediHelp rates the interaction as major. Dronedarone and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone, a moderate CYP3A4 inhibitor, can raise lomitapide levels, increasing risk of hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Dronedarone and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if needed, limit lomitapide dose per labeling and monitor liver enzymes.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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