Drug interactions
Dronedarone + Macimorelin
Severity: Major
Dronedarone and Macimorelin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation, and dronedarone prolongs the QT interval, so together they raise the risk of torsades de pointes. The diagnostic test is a single-dose procedure, so the exposure can usually be planned around.
What this interaction means in plain words
Dronedarone and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Macimorelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Avoid giving macimorelin to patients taking dronedarone, or use an alternative diagnostic test. If testing is essential, allow adequate washout of dronedarone first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Dronedarone with Macimorelin?
MediHelp rates the interaction as major. Dronedarone and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation, and dronedarone prolongs the QT interval, so together they raise the risk of torsades de pointes. The diagnostic test is a single-dose procedure, so the exposure can usually be planned around.
How serious is the interaction between Dronedarone and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking dronedarone, or use an alternative diagnostic test. If testing is essential, allow adequate washout of dronedarone first.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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