Drug interactions
Dronedarone + Nisoldipine
Severity: Moderate
Dronedarone and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, can raise nisoldipine concentrations, which are heavily dependent on first-pass CYP3A4 metabolism. This may cause hypotension, peripheral edema, flushing and reflex tachycardia, and dronedarone itself can add to bradycardia and conduction effects.
What this interaction means in plain words
Dronedarone and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Dronedarone inhibits intestinal and hepatic CYP3A4, reducing the first-pass metabolism of nisoldipine.
What to do
Start nisoldipine at a low dose and titrate to blood pressure response; monitor heart rate, blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Dronedarone with Nisoldipine?
MediHelp rates the interaction as moderate. Dronedarone and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone, a moderate CYP3A4 inhibitor, can raise nisoldipine concentrations, which are heavily dependent on first-pass CYP3A4 metabolism. This may cause hypotension, peripheral edema, flushing and reflex tachycardia, and dronedarone itself can add to bradycardia and conduction effects.
How serious is the interaction between Dronedarone and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nisoldipine at a low dose and titrate to blood pressure response; monitor heart rate, blood pressure and ECG.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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